PATJ and NRXN2

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PATJ	NRXN2
Description		PATJ crumbs cell polarity complex component	neurexin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Integral Component Of Membrane Protein-containing Complex Presynapse
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Bicellular Tight Junction Assembly Tight Junction Assembly	Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering
Pathways			Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)	Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 29273807) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Serum uric acid levels ( 30993211 29403010) Urate levels ( 21768215 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 29558500)
Interacting Genes		35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3	9 interacting genes: AFDN CASK DDX24 MACF1 MAPK6 NLGN1 NLGN2 NLGN3 PATJ
Entrez ID		10207	9379
HPRD ID		04434	11859
Ensembl ID		ENSG00000132849	ENSG00000110076
Uniprot IDs			G5E9G7 P58401 Q9P2S2
PDB IDs			4NXR
Enriched GO Terms of Interacting Partners?
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