PATJ and CRB3

Data Source:
HPRD (in vitro, in vivo)

		PATJ	CRB3
Description		PATJ crumbs cell polarity complex component	crumbs cell polarity complex component 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding SH3 Domain Binding Protein Domain Specific Binding
	Biological Process	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Bicellular Tight Junction Assembly Tight Junction Assembly	Bicellular Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Cell Junction Assembly
Pathways			Tight junction interactions
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)
Interacting Genes		35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3	28 interacting genes: ANKRD46 BCL2L13 BET1 FUNDC2 HMOX1 HMOX2 NDUFA3 PALS1 PARD6A PATJ PLLP PLP2 PSENEN PSMA3 RABAC1 SERF1A SERF1B SERP1 SLC39A9 STX5 TECR TMEM222 TREX1 UBIAD1 VAMP1 VTI1B WDR83 YIPF6
Entrez ID		10207	92359
HPRD ID		04434	16749
Ensembl ID		ENSG00000132849	ENSG00000130545
Uniprot IDs			Q9BUF7
PDB IDs			5I7Z
Enriched GO Terms of Interacting Partners?
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