PATJ and GRIN2C

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PATJ	GRIN2C
Description		PATJ crumbs cell polarity complex component	glutamate ionotropic receptor NMDA type subunit 2C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	NMDA Glutamate Receptor Activity Protein Binding Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Bicellular Tight Junction Assembly Tight Junction Assembly	Glutamate Receptor Signaling Pathway Brain Development Response To Wounding Calcium-mediated Signaling Directional Locomotion Ionotropic Glutamate Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Regulation Of Synaptic Plasticity Neuromuscular Process Controlling Balance Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane
Pathways			Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Memantine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)	Congenital heart disease (maternal effect) ( 28468790)
Interacting Genes		35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3	6 interacting genes: DLG3 DLG4 DLGAP1 ERBIN IL16 PATJ
Entrez ID		10207	2905
HPRD ID		04434	00699
Ensembl ID		ENSG00000132849	ENSG00000161509
Uniprot IDs			H0Y2V8 O15398 Q14957 Q8IW23
PDB IDs
Enriched GO Terms of Interacting Partners?
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