PATJ and GRIN2A

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		PATJ	GRIN2A
Description		PATJ crumbs cell polarity complex component	glutamate ionotropic receptor NMDA type subunit 2A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cytoplasmic Vesicle Membrane Presynaptic Membrane Dendritic Spine Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Protein Binding Zinc Ion Binding Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity
	Biological Process	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Bicellular Tight Junction Assembly Tight Junction Assembly	Startle Response Response To Amphetamine Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Brain Development Learning Or Memory Memory Visual Learning Response To Wounding Sensory Perception Of Pain Calcium-mediated Signaling Neurogenesis Sleep Directional Locomotion Ionotropic Glutamate Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Dopamine Metabolic Process Serotonin Metabolic Process Response To Drug Positive Regulation Of Apoptotic Process Response To Ethanol Regulation Of Synaptic Plasticity Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Activation Of Cysteine-type Endopeptidase Activity Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Protein Localization To Postsynaptic Membrane Cellular Response To Amyloid-beta Regulation Of NMDA Receptor Activity
Pathways			Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Glycine Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Felbamate Memantine Halothane Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Chronic kidney disease ( 26420894) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Hallux valgus ( 32131869) Hepatitis B ( 22004137) Laryngeal squamous cell carcinoma ( 25194280) Lung function (FVC) ( 30804560) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 28991256 25056061 29483656 30285260) Tenofovir clearance in HIV infection ( 26148204) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)
Interacting Genes		35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3	29 interacting genes: ACTN1 AKT1 AP1M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CASK CDK5 DLG1 DLG2 DLG3 DLG4 DLGAP1 FYN GRIN1 GRIN2B GRIN3A GRIN3B IL16 NEDD4 PATJ PLCG1 PRKCA PTK2B PTPN4 RGS3 SPTAN1 SRC
Entrez ID		10207	2903
HPRD ID		04434	00698
Ensembl ID		ENSG00000132849	ENSG00000183454
Uniprot IDs			A0A6Q8PGD2 Q12879 Q547U9 Q59EW6
PDB IDs			3NFL 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH
Enriched GO Terms of Interacting Partners?
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