PSME3 and PFDN5

Data Source:
BioGRID (two hybrid, two hybrid)

		PSME3	PFDN5
Description		proteasome activator subunit 3	prefoldin subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Membrane	Nucleus Cytoplasm Cytosol Prefoldin Complex Intermediate Filament Cytoskeleton
	Molecular Function	P53 Binding Protein Binding Identical Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding	Amyloid-beta Binding Transcription Corepressor Activity Protein Binding Unfolded Protein Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process Cell Cycle Positive Regulation Of Endopeptidase Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Transcription, DNA-templated Protein Folding Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Amyloid Fibril Formation
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS
Interacting Genes		64 interacting genes: ABCF3 ADAP1 AICDA ATN1 ATP5F1B BBS2 CASP3 CASP6 CASP7 CDC25B CDC42 CDR2L CHEK2 COIL CREBBP DEPTOR DIP2A DMRT3 DTNBP1 DVL3 EAF1 EAF2 FAM90A1 FBXL12 FBXL19 FOXD4L1 FXR2 GPATCH2L HSPA5 INPP5J ITPKB KANSL1 KBTBD7 KLF2 LNX1 MDM2 MEOX2 NCOA3 NTAQ1 NUDT18 PFDN5 PIAS1 PICK1 PRKAB2 PRR13 RDX RNF111 RPH3AL RPS27 SERF2 SIRT1 SMURF1 SPG7 TBP TBXA2R THAP10 TNFAIP8L1 TP53 TXN2 UBE2H UBE2I WDR25 YWHAQ ZCCHC10	114 interacting genes: ABI2 ANKRD55 BCAS2 BCL6 BHLHE40 BRMS1 C10orf55 C10orf62 C20orf85 C22orf39 C4orf45 C7orf31 CALCOCO2 CCDC198 CSPP1 DMRT3 DOK4 DOK5 ELK3 ESPNL FAAP20 FAM102A FAM110A FAM214B FAM221A FAM222B FAM90A1 GLRX3 GLYCTK GPANK1 GSTO2 GUCD1 HAPLN2 HHEX HOXB9 HOXC8 IKBKG IKZF3 IL16 INCA1 IRX2 IRX6 ITSN1 KCTD9 KDM1A KLHL38 KLHL42 LARP4 LNX1 MAP2K5 METTL21A MISP MRPL45 MYC MYOT MYOZ1 NEUROG2 NOXA1 NTAQ1 PATZ1 PAX9 PFDN2 PFDN6 PHF1 PHF24 PILRA PITX1 PITX2 POGZ PPP1R32 PRKAB2 PRPF18 PRR35 PSMB4 PSMB8 PSME3 RIBC1 RIPPLY1 RSRC2 RUSC1 SAXO1 SCNM1 SDCBP SHISA6 SLAIN1 SMAP1 SMG9 SNAI1 SNRNP25 SNRPB SOHLH1 SPAG8 SPG21 STK19 SYCE1L SYT17 TAF6L TBX3 TCF19 TFG TLE5 TP73 TRAPPC6A TRIM28 TUBA1B TUBA3C VAX2 VBP1 VEZF1 VGLL1 WDR25 YPEL5 ZC2HC1C ZNF148
Entrez ID		10197	5204
HPRD ID		05500	05359
Ensembl ID		ENSG00000131467	ENSG00000123349
Uniprot IDs		A0A024R203 B3KQ25 P61289 Q6MZZ1 V9HWJ8	Q99471
PDB IDs			6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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