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PSME3 and DMRT3
Data Source:
BioGRID
(two hybrid)
PSME3
DMRT3
Description
proteasome activator subunit 3
doublesex and mab-3 related transcription factor 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Activator Complex
Membrane
Chromatin
Nucleus
Molecular Function
P53 Binding
Protein Binding
Identical Protein Binding
Endopeptidase Activator Activity
MDM2/MDM4 Family Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
Cell Cycle
Positive Regulation Of Endopeptidase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Sex Differentiation
Adult Walking Behavior
Transmission Of Nerve Impulse
Ventral Spinal Cord Interneuron Specification
Regulation Of Odontogenesis Of Dentin-containing Tooth
Male Sex Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Dupuytren's disease (
28886342
)
Major depressive disorder (
23377640
)
Metabolite levels (
23823483
)
Night sleep phenotypes (
27126917
)
Response to Homoharringtonine (cytotoxicity) (
25628645
)
Interacting Genes
64 interacting genes:
ABCF3
ADAP1
AICDA
ATN1
ATP5F1B
BBS2
CASP3
CASP6
CASP7
CDC25B
CDC42
CDR2L
CHEK2
COIL
CREBBP
DEPTOR
DIP2A
DMRT3
DTNBP1
DVL3
EAF1
EAF2
FAM90A1
FBXL12
FBXL19
FOXD4L1
FXR2
GPATCH2L
HSPA5
INPP5J
ITPKB
KANSL1
KBTBD7
KLF2
LNX1
MDM2
MEOX2
NCOA3
NTAQ1
NUDT18
PFDN5
PIAS1
PICK1
PRKAB2
PRR13
RDX
RNF111
RPH3AL
RPS27
SERF2
SIRT1
SMURF1
SPG7
TBP
TBXA2R
THAP10
TNFAIP8L1
TP53
TXN2
UBE2H
UBE2I
WDR25
YWHAQ
ZCCHC10
86 interacting genes:
AKAP8L
ASPG
ATN1
ATP6V0D1
C11orf1
CCNDBP1
CYSRT1
FHL3
FHL5
FOXN1
FRS3
GPSM1
GRN
HSF2BP
INCA1
KHDRBS3
KPRP
KRT31
KRT34
KRT35
KRT36
KRT38
KRT40
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP19-5
KRTAP2-3
KRTAP2-4
KRTAP3-1
KRTAP3-3
KRTAP5-7
KRTAP5-9
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
LASP1
LMO2
MDFI
MEOX2
MGAT5B
MID2
MTUS2
MYOZ3
NBPF19
NFKBID
NHLRC4
NOTCH2NLA
OIP5
PFDN5
PLEKHF2
PLSCR1
PRDM14
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMA3
PSME3
RBPMS
REL
RFX6
RUSC1
SAT1
SPAG8
TCF4
TLE5
TRAF1
TRIM23
TRIM27
TRIP6
TSC1
TTC19
UBASH3B
USP54
WWOX
YPEL3
ZFY
ZMYND12
ZNF438
Entrez ID
10197
58524
HPRD ID
05500
16827
Ensembl ID
ENSG00000131467
ENSG00000064218
Uniprot IDs
A0A024R203
B3KQ25
P61289
Q6MZZ1
V9HWJ8
Q9NQL9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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