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PSME3 and PRKAB2
Data Source:
BioGRID
(two hybrid)
PSME3
PRKAB2
Description
proteasome activator subunit 3
protein kinase AMP-activated non-catalytic subunit beta 2
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Activator Complex
Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleotide-activated Protein Kinase Complex
Molecular Function
P53 Binding
Protein Binding
Identical Protein Binding
Endopeptidase Activator Activity
MDM2/MDM4 Family Protein Binding
AMP-activated Protein Kinase Activity
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
Cell Cycle
Positive Regulation Of Endopeptidase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Cell Cycle Arrest
Signal Transduction
Macroautophagy
Regulation Of Macroautophagy
Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Catalytic Activity
Regulation Of Primary Metabolic Process
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Interacting Genes
64 interacting genes:
ABCF3
ADAP1
AICDA
ATN1
ATP5F1B
BBS2
CASP3
CASP6
CASP7
CDC25B
CDC42
CDR2L
CHEK2
COIL
CREBBP
DEPTOR
DIP2A
DMRT3
DTNBP1
DVL3
EAF1
EAF2
FAM90A1
FBXL12
FBXL19
FOXD4L1
FXR2
GPATCH2L
HSPA5
INPP5J
ITPKB
KANSL1
KBTBD7
KLF2
LNX1
MDM2
MEOX2
NCOA3
NTAQ1
NUDT18
PFDN5
PIAS1
PICK1
PRKAB2
PRR13
RDX
RNF111
RPH3AL
RPS27
SERF2
SIRT1
SMURF1
SPG7
TBP
TBXA2R
THAP10
TNFAIP8L1
TP53
TXN2
UBE2H
UBE2I
WDR25
YWHAQ
ZCCHC10
170 interacting genes:
ABHD11
ADAMTSL4
ANAPC11
ARID5A
AUNIP
AVP
BANP
BEND5
BHLHB9
BLZF1
C11orf1
C19orf54
C2orf42
C3orf36
CALCOCO2
CASP2
CASP6
CCDC28B
CCDC33
CDC14B
CDSN
CDX4
CFP
CREB3L1
CRX
CSNK2B
CYSRT1
DAO
DDAH2
DDIT4L
DICER1
DOK3
DST
ELL2
EPM2A
ESM1
FDX1
FLNC
GATA1
GATAD2B
GCSAML
GET4
GOLGA2
GOLGA6L9
GORASP2
GRAPL
GRN
GSC2
IHO1
IKZF1
IKZF3
IL37
IRAK1BP1
KATNBL1
KCTD5
KHDC4
KLF15
KRBOX4
KRT31
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP3-3
KRTAP4-12
KRTAP4-2
KRTAP4-5
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LHX3
LRIF1
LZTS1
LZTS2
MAGED1
MAJIN
MDFI
MEOX2
METTL27
MORN3
NAB2
NEBL
NHLRC4
NUTM1
OXER1
PDE6G
PDE6H
PFDN5
PIAS2
PNMA1
PPP1R13B
PPP1R16A
PRDM14
PRKAA1
PRKAG1
PRKAG2
PSMD11
PSME3
PYGM
QKI
RAB3IP
RACK1
RBM48
RBPMS
REL
RHEBL1
RIMBP3
RNF144B
ROR2
RPH3AL
SAMD4A
SERTAD2
SMARCB1
SMUG1
SPRY1
SPRY2
SSC4D
SSX2IP
STX11
STX19
TADA2A
TASOR2
TCF12
TCF19
TCF4
TCF7L2
TGM7
TLE5
TNNI1
TP53
TP53BP2
TRAF1
TRAF2
TRIB3
TRIM10
TRIM14
TRIM35
TRIM42
TRIM54
TRIM55
TRIM63
TSR2
TTC23
UBXN11
USP54
VBP1
VPS28
WDR83
YPEL3
YY1AP1
ZBTB32
ZC2HC1C
ZFP90
ZMYND19
ZNF177
ZNF236
ZNF474
ZNF526
ZNF559-ZNF177
ZNF581
Entrez ID
10197
5565
HPRD ID
05500
04117
Ensembl ID
ENSG00000131467
ENSG00000131791
Uniprot IDs
A0A024R203
B3KQ25
P61289
Q6MZZ1
V9HWJ8
O43741
PDB IDs
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2YA3
4CFH
4EAI
4EAJ
4RER
4REW
6B2E
Enriched GO Terms of Interacting Partners
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