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PSME3 and PICK1
Data Source:
BioGRID
(two hybrid)
PSME3
PICK1
Description
proteasome activator subunit 3
protein interacting with PRKCA 1
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Activator Complex
Membrane
Cytoplasm
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Synaptic Vesicle
Postsynaptic Density
Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Presynaptic Membrane
Neuron Projection
Synapse
Perinuclear Region Of Cytoplasm
Postsynaptic Early Endosome
Molecular Function
P53 Binding
Protein Binding
Identical Protein Binding
Endopeptidase Activator Activity
MDM2/MDM4 Family Protein Binding
G Protein-coupled Receptor Binding
Protein Kinase C Binding
Signaling Receptor Binding
Protein Binding
Phospholipid Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Metal Ion Binding
Actin Filament Binding
Arp2/3 Complex Binding
Membrane Curvature Sensor Activity
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
Cell Cycle
Positive Regulation Of Endopeptidase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Receptor Internalization
Protein Phosphorylation
Intracellular Protein Transport
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Monoamine Transport
Glial Cell Development
Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Cellular Response To Decreased Oxygen Levels
Cellular Response To Glucose Starvation
DNA Methylation Involved In Embryo Development
DNA Methylation Involved In Gamete Generation
Receptor Clustering
Neuronal Ion Channel Clustering
Regulation Of Insulin Secretion
Long-term Synaptic Depression
Dendritic Spine Organization
Dendritic Spine Maintenance
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Cell surface interactions at the vascular wall
Trafficking of GluR2-containing AMPA receptors
Drugs
Diseases
GWAS
Body fat percentage (
26833246
)
Brain morphology (MOSTest) (
32665545
)
Mean platelet volume (
32888494
)
Interacting Genes
64 interacting genes:
ABCF3
ADAP1
AICDA
ATN1
ATP5F1B
BBS2
CASP3
CASP6
CASP7
CDC25B
CDC42
CDR2L
CHEK2
COIL
CREBBP
DEPTOR
DIP2A
DMRT3
DTNBP1
DVL3
EAF1
EAF2
FAM90A1
FBXL12
FBXL19
FOXD4L1
FXR2
GPATCH2L
HSPA5
INPP5J
ITPKB
KANSL1
KBTBD7
KLF2
LNX1
MDM2
MEOX2
NCOA3
NTAQ1
NUDT18
PFDN5
PIAS1
PICK1
PRKAB2
PRR13
RDX
RNF111
RPH3AL
RPS27
SERF2
SIRT1
SMURF1
SPG7
TBP
TBXA2R
THAP10
TNFAIP8L1
TP53
TXN2
UBE2H
UBE2I
WDR25
YWHAQ
ZCCHC10
365 interacting genes:
ABT1
AEBP2
AFDN
AKT1
AKT2
ALKBH8
AP1M1
AP1S1
APTX
AQP1
ARF1
ARF3
ARHGEF3
ARHGEF5
ARL6IP1
ARMCX1
ASIC1
ASIC2
ATP5IF1
ATXN1L
ATXN3
ATXN7
ATXN7L3
AVPI1
BAHD1
BCL2L14
BEX1
BLK
BLOC1S2
BOLA3
BRD1
BTG2
BUD31
BYSL
C1orf35
C2CD5
C4orf46
C8orf33
CARD9
CBX8
CCDC102B
CCDC103
CCDC187
CCNH
CDC42EP2
CDC73
CDCA7L
CDK2AP1
CDKL3
CDKN2B
CDKN2D
CEP19
CEP290
CEP57L1
CEP89
CEP95
CGGBP1
CHMP1B
CIC
COIL
CPNE2
CPNE7
CRY2
CSNK2A2
CTNNB1
CTSG
CUTC
CWF19L2
CYP21A2
DCTD
DCUN1D5
DDX55
DDX6
DMC1
DMD
DNAJB13
DNTTIP1
DNTTIP2
DPF2
DRAP1
DTNB
DUSP29
EAF1
EEF2KMT
EFHC2
EFNB1
EFNB2
EHD2
EHHADH
EIF1AD
EIF3D
EIF4A3
EIF4EBP1
EIF4H
EIF5A
ENKD1
EPHB2
EPM2AIP1
ERBB2
ERBIN
ESCO2
EXOSC5
F11R
FAM161A
FAM161B
FAM207A
FAM214B
FAM219B
FAM90A1
FAM9A
FBXL3
FBXL8
FGF16
FKBP6
FLYWCH1
FXN
GADD45GIP1
GAS2L2
GFI1
GFI1B
GLYCTK
GPATCH11
GPATCH2
GPC4
GPKOW
GRB10
GRB7
GRIA1
GRIA2
GRIA3
GRIA4
GRIK1
GRIK2
GRIP1
GRM3
GRM7
GRXCR1
GTF2E2
GTPBP2
HDAC4
HEXIM2
HMBOX1
HMBS
HMG20A
HOPX
HOXA5
HSD17B14
HSF2
HSF2BP
ID2
IHO1
IL16
ILF2
INO80B
INO80E
INPP5J
IP6K1
ISCU
JAM3
JRK
KAT5
KCTD1
KCTD6
KCTD9
KIAA1328
L3MBTL2
LCLAT1
LCN2
LGALS14
LMO1
LMO3
LONRF1
LRP2BP
LRRC73
LZTFL1
LZTS1
MAGEA4
MAGEB4
MAP2K6
MAPK9
MAPRE3
MAZ
MBD3
MCM10
MEOX2
MGME1
MID2
MNS1
MOB3C
MORF4L1
MORF4L2
MORN3
MOS
MRI1
MRNIP
MSRB3
MSS51
MTA1
MTG1
NATD1
NCOA5
NDEL1
NECAB2
NECTIN2
NECTIN4
NEK6
NME7
NMNAT1
NOC4L
OARD1
OPTN
OSBP2
OSGIN1
OSTF1
PAFAH1B3
PAX6
PBX4
PCBD1
PDCD5
PDS5A
PEBP1
PHF19
PIBF1
PKN1
PKNOX2
PLEKHA7
PNKP
PNO1
POLL
POLR3C
PPARA
PPL
PRKCA
PRKCG
PRKN
PRLHR
PRPF18
PRPF31
PRPF40A
PSMA1
PSME3
PTRH1
QARS1
RAD51D
RASAL3
REEP6
REL
RFC3
RIMS3
RIN1
RNF8
RNPS1
ROBO3
ROPN1
RPIA
RPP25
RRP8
RXRB
RXRG
SACS
SCAND1
SCNM1
SEMA3B
SEPTIN1
SERBP1
SERTAD1
SERTAD3
SH2D4A
SH3GLB2
SHFL
SLC6A3
SLIRP
SMARCB1
SMARCD1
SNRNP25
SNRPA1
SNRPB2
SNW1
SPANXN2
SPATC1L
SPEG
SSNA1
STK19
STK4
SYT17
TBC1D22B
TBC1D26
TBC1D7
TCEA2
TCEANC
TCEANC2
TDO2
TEX101
TFIP11
THAP6
THAP7
TLE5
TLNRD1
TPM4
TRAF4
TRAF5
TRIM44
TRIM54
TRIML2
TRMT2A
TSGA10IP
TSN
TSTD2
TTC23
TTC23L
TXNDC9
TXNL4B
TYW3
UBE2E3
UBE2K
UBQLN4
USHBP1
USP2
USP7
UTP3
VAX1
VEZF1
VPS25
WT1
XPA
YES1
YPEL2
YTHDC1
ZBED1
ZBTB2
ZBTB24
ZBTB49
ZFHX3
ZFP2
ZFP91
ZMAT2
ZMYND12
ZNF165
ZNF17
ZNF205
ZNF250
ZNF264
ZNF276
ZNF286A
ZNF329
ZNF330
ZNF35
ZNF408
ZNF410
ZNF414
ZNF417
ZNF438
ZNF497
ZNF524
ZNF575
ZNF576
ZNF593
ZNF624
ZNF691
ZNF71
ZNF764
ZNF774
ZSCAN21
ZSCAN23
ZZZ3
Entrez ID
10197
9463
HPRD ID
05500
16176
Ensembl ID
ENSG00000131467
ENSG00000100151
Uniprot IDs
A0A024R203
B3KQ25
P61289
Q6MZZ1
V9HWJ8
A0A024R1J5
Q9NRD5
PDB IDs
2GZV
6AR4
6BJN
6BJO
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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