DCAF12 and SIGMAR1

		DCAF12	SIGMAR1
Description		DDB1 and CUL4 associated factor 12	sigma non-opioid intracellular receptor 1
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cul4-RING E3 Ubiquitin Ligase Complex	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Postsynaptic Density Membrane Integral Component Of Membrane Growth Cone Cytoplasmic Vesicle Postsynaptic Density Membrane
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	G Protein-coupled Opioid Receptor Activity Protein Binding
	Biological Process	Regulation Of Autophagy Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Lipid Transport Nervous System Development Cell Death In Response To Hydrogen Peroxide G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization
Pathways			Potential therapeutics for SARS
Drugs			Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Noscapine Captodiame Pentoxyverine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) BRCA1/2-negative high-risk breast cancer ( 30323354) Daytime nap ( 33568662) Estimated glomerular filtration rate ( 31015462 30604766) Granulocyte percentage of myeloid white cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Platelet distribution width ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		4 interacting genes: BMPR1B CUL4B SIGMAR1 TGFBR1	14 interacting genes: ANK2 DCAF12 DNAJB5 GHSR GNE ITPR3 NFX1 PDZD11 PHF24 RECK RUSC2 SPAG8 SPINK4 VCP
Entrez ID		25853	10280
HPRD ID		10031	03580
Ensembl ID		ENSG00000198876	ENSG00000147955
Uniprot IDs		Q5T6F0	A2A3U5 B4DR71 Q99720
PDB IDs		3I7P	5HK1 5HK2 6DJZ 6DK0 6DK1
Enriched GO Terms of Interacting Partners?
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