DCAF12 and BMPR1B

Number of citations of the paper that reports this interaction (PubMedID 15761153)
269

Data Source:
HPRD (in vivo)

		DCAF12	BMPR1B
Description		DDB1 and CUL4 associated factor 12	bone morphogenetic protein receptor type 1B
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cul4-RING E3 Ubiquitin Ligase Complex	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Phosphatase Activator Activity BMP Binding Protein Serine/threonine Kinase Activator Activity SMAD Binding Metal Ion Binding BMP Receptor Activity Transcription Regulator Activator Activity
	Biological Process	Regulation Of Autophagy Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Osteoblast Differentiation Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways			Signaling by BMP
Drugs			Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) BRCA1/2-negative high-risk breast cancer ( 30323354) Daytime nap ( 33568662) Estimated glomerular filtration rate ( 31015462 30604766) Granulocyte percentage of myeloid white cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Platelet distribution width ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 33020668) Diverticular disease ( 30177863) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Maximum stenosis ( 32469969) Opioid dependence (time to event) ( 34124712) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Systolic blood pressure ( 30224653 30578418) Waist-hip ratio ( 28552196)
Interacting Genes		4 interacting genes: BMPR1B CUL4B SIGMAR1 TGFBR1	65 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SLC39A8 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		25853	658
HPRD ID		10031	04457
Ensembl ID		ENSG00000198876	ENSG00000138696
Uniprot IDs		Q5T6F0	A8KAE3 O00238
PDB IDs		3I7P	3MDY
Enriched GO Terms of Interacting Partners?
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