SIGMAR1 and DCAF12

		SIGMAR1	DCAF12
Description		sigma non-opioid intracellular receptor 1	DDB1 and CUL4 associated factor 12
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GO Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Postsynaptic Density Membrane Integral Component Of Membrane Growth Cone Cytoplasmic Vesicle Postsynaptic Density Membrane	Cytoplasm Centrosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	G Protein-coupled Opioid Receptor Activity Protein Binding	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Lipid Transport Nervous System Development Cell Death In Response To Hydrogen Peroxide G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization	Regulation Of Autophagy Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		Potential therapeutics for SARS
Drugs		Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Noscapine Captodiame Pentoxyverine
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) BRCA1/2-negative high-risk breast cancer ( 30323354) Daytime nap ( 33568662) Estimated glomerular filtration rate ( 31015462 30604766) Granulocyte percentage of myeloid white cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Platelet distribution width ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		14 interacting genes: ANK2 DCAF12 DNAJB5 GHSR GNE ITPR3 NFX1 PDZD11 PHF24 RECK RUSC2 SPAG8 SPINK4 VCP	4 interacting genes: BMPR1B CUL4B SIGMAR1 TGFBR1
Entrez ID		10280	25853
HPRD ID		03580	10031
Ensembl ID		ENSG00000147955	ENSG00000198876
Uniprot IDs		A2A3U5 B4DR71 Q99720	Q5T6F0
PDB IDs		5HK1 5HK2 6DJZ 6DK0 6DK1	3I7P
Enriched GO Terms of Interacting Partners?
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