SIGMAR1 and GHSR

Number of citations of the paper that reports this interaction (PubMedID 29876881)
3

Data Source:
BioGRID (fluorescent resonance energy transfer)

		SIGMAR1	GHSR
Description		sigma non-opioid intracellular receptor 1	growth hormone secretagogue receptor
Image
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Postsynaptic Density Membrane Integral Component Of Membrane Growth Cone Cytoplasmic Vesicle Postsynaptic Density Membrane	Plasma Membrane Cell Surface Neuron Projection Membrane Raft Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Integral Component Of Synaptic Membrane
	Molecular Function	G Protein-coupled Opioid Receptor Activity Protein Binding	Growth Hormone Secretagogue Receptor Activity G Protein-coupled Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding
	Biological Process	Lipid Transport Nervous System Development Cell Death In Response To Hydrogen Peroxide G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization	G Protein-coupled Receptor Signaling Pathway Spermatogenesis Learning Or Memory Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Growth Hormone Secretion Response To Food Negative Regulation Of Appetite Positive Regulation Of Appetite Response To Follicle-stimulating Hormone Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Ghrelin Secretion Positive Regulation Of Multicellular Organism Growth Regulation Of Hindgut Contraction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Regulation Of Growth Hormone Secretion Response To Growth Hormone Cellular Response To Lipopolysaccharide Response To Dexamethasone Negative Regulation Of Locomotion Involved In Locomotory Behavior Cellular Response To Thyroid Hormone Stimulus Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Response To Monosodium Glutamate Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Macrophage Apoptotic Process
Pathways		Potential therapeutics for SARS	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Noscapine Captodiame Pentoxyverine	Ulimorelin Macimorelin Echinacoside
Diseases
GWAS			Chronotype ( 30696823) Cocaine dependence ( 31212010) Height ( 20881960 25282103 25429064 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: ANK2 DCAF12 DNAJB5 GHSR GNE ITPR3 NFX1 PDZD11 PHF24 RECK RUSC2 SPAG8 SPINK4 VCP	4 interacting genes: CORT DRD1 GHRL SIGMAR1
Entrez ID		10280	2693
HPRD ID		03580	03541
Ensembl ID		ENSG00000147955	ENSG00000121853
Uniprot IDs		A2A3U5 B4DR71 Q99720	Q92847
PDB IDs		5HK1 5HK2 6DJZ 6DK0 6DK1	6KO5
Enriched GO Terms of Interacting Partners?
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