TLK1 and TPM3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TLK1	TPM3
Description		tousled like kinase 1	tropomyosin 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Molecular_function Protein Binding Actin Filament Binding
	Biological Process	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Muscle Contraction Actin Filament Organization Muscle Filament Sliding
Pathways			Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Phenethyl Isothiocyanate
Diseases			Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS		Health literacy ( 31250787) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 27863252)	Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		15 interacting genes: ASF1A ASF1B AURKA CHEK1 H1-1 LUZP4 MBP NBN PTPN11 RAD9A SNAP23 TLK2 TPM3 UBE3C YWHAE	44 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CCDC102B CCDC114 CCDC146 CCHCR1 CNN1 DVL2 FAM9C FBXO5 HDDC3 HOOK2 HSF2 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 NEK2 NOD2 OIP5 PBX3 S100A2 S100A4 SMAD3 SUMO4 SYCE1 TFPT THAP1 TLK1 TMOD1 TMOD2 TNNT1 TRAP1 TRIM27 TRIP6 VPS52 WASH3P
Entrez ID		9874	7170
HPRD ID		12232	01840
Ensembl ID		ENSG00000198586	ENSG00000143549
Uniprot IDs		Q9UKI8	A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4I4 B4DQ80 P06753
PDB IDs			6OTN
Enriched GO Terms of Interacting Partners?
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