TPM3 and IFIT3

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		TPM3	IFIT3
Description		tropomyosin 3	interferon induced protein with tetratricopeptide repeats 3
Image
GO Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Molecular_function Protein Binding Actin Filament Binding	Molecular_function RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Muscle Contraction Actin Filament Organization Muscle Filament Sliding	Negative Regulation Of Cell Proliferation Response To Virus Cellular Response To Interferon-alpha Negative Regulation Of Apoptotic Process Defense Response To Virus Type I Interferon Signaling Pathway
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	Interferon alpha/beta signaling
Drugs		Phenethyl Isothiocyanate
Diseases		Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS		Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032)	Hormone measurements ( 30576415)
Interacting Genes		44 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CCDC102B CCDC114 CCDC146 CCHCR1 CNN1 DVL2 FAM9C FBXO5 HDDC3 HOOK2 HSF2 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 NEK2 NOD2 OIP5 PBX3 S100A2 S100A4 SMAD3 SUMO4 SYCE1 TFPT THAP1 TLK1 TMOD1 TMOD2 TNNT1 TRAP1 TRIM27 TRIP6 VPS52 WASH3P	19 interacting genes: A2M APOE CYP2C8 DEUP1 ECSIT FANCA HAUS1 IFIT1 IFIT2 IFIT5 LONP1 LVRN MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM1 TPM3
Entrez ID		7170	3437
HPRD ID		01840	05228
Ensembl ID		ENSG00000143549	ENSG00000119917
Uniprot IDs		A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4I4 B4DQ80 P06753	O14879 Q5T765
PDB IDs		6OTN	6C6K
Enriched GO Terms of Interacting Partners?
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