TPM3 and HSF2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		TPM3	HSF2
Description		tropomyosin 3	heat shock transcription factor 2
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GO Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Extracellular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Molecular_function Protein Binding Actin Filament Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding
	Biological Process	Muscle Contraction Actin Filament Organization Muscle Filament Sliding	Transcription By RNA Polymerase II Spermatogenesis Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Heat Stress
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs		Phenethyl Isothiocyanate
Diseases		Congenital fiber type disproportion (CFTD) Cap myopathy Thyroid cancer Nemaline myopathy
GWAS		Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Platelet count ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032)	Atrial fibrillation ( 28416822 30061737 29892015) Disease progression in age-related macular degeneration ( 29346644) Lymphocyte counts ( 27863252) Optic cup area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Pulse pressure ( 30224653 27841878) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Word reading ( 30741946)
Interacting Genes		44 interacting genes: ACTA1 ACTB BLOC1S6 C1orf216 CCDC102B CCDC114 CCDC146 CCHCR1 CNN1 DVL2 FAM9C FBXO5 HDDC3 HOOK2 HSF2 IFIT3 IKBIP KCNE1 KIFC3 KXD1 LCA5L LURAP1 MAD1L1 MAGEA11 NEK2 NOD2 OIP5 PBX3 S100A2 S100A4 SMAD3 SUMO4 SYCE1 TFPT THAP1 TLK1 TMOD1 TMOD2 TNNT1 TRAP1 TRIM27 TRIP6 VPS52 WASH3P	15 interacting genes: CDC20 CDC27 CUL3 HSF1 HSF2BP MTUS2 NCAPG NUP62 PCGF2 PPP2R1A SUMO2 SUMO3 TPM3 UBE2I WDR5
Entrez ID		7170	3298
HPRD ID		01840	00779
Ensembl ID		ENSG00000143549	ENSG00000025156
Uniprot IDs		A0A087WWU8 A0A0S2Z4G4 A0A0S2Z4I4 B4DQ80 P06753	Q03933 Q9BS48
PDB IDs		6OTN	5D8K 5D8L 5HDK
Enriched GO Terms of Interacting Partners?
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