UBE2L6 and CBLC

Number of citations of the paper that reports this interaction (PubMedID 19549727)
67

Data Source:
BioGRID (two hybrid)

		UBE2L6	CBLC
Description		ubiquitin conjugating enzyme E2 L6	Cbl proto-oncogene C
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytosol	Plasma Membrane Membrane Raft
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Translesion Synthesis ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)
Interacting Genes		38 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM8 UBA1 UBA6 UBA7 UBE3A	53 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 ZAP70
Entrez ID		9246	23624
HPRD ID		04867	09765
Ensembl ID		ENSG00000156587	ENSG00000142273
Uniprot IDs		O14933	Q9ULV8
PDB IDs		1WZV 1WZW 2KJH	3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?
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