UBE2L6 and LONRF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		UBE2L6	LONRF1
Description		ubiquitin conjugating enzyme E2 L6	LON peptidase N-terminal domain and ring finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytosol	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Metal Ion Binding
	Biological Process	Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Translesion Synthesis ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process	Protein Polyubiquitination
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Colorectal cancer (diet interaction) ( 24743840)
Interacting Genes		38 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM8 UBA1 UBA6 UBA7 UBE3A	33 interacting genes: ADAMTSL4 ALAS1 ATG9A BRCA1 BYSL CALCOCO2 CRX EFHC2 GORASP1 GORASP2 HSPB1 IHO1 IKZF2 IQCF2 KAT5 KCTD9 KRT31 KRTAP13-1 LHX4 NR4A1 NTAQ1 PLSCR1 RBPMS SFN SPRY2 STAU1 STX11 TRIM42 TRIM9 UBE2L6 UCHL3 USP2 XIAP
Entrez ID		9246	91694
HPRD ID		04867	08674
Ensembl ID		ENSG00000156587	ENSG00000154359
Uniprot IDs		O14933	Q17RB8
PDB IDs		1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?
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