L3MBTL2 and MEAF6

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		L3MBTL2	MEAF6
Description		L3MBTL histone methyl-lysine binding protein 2	MYST/Esa1 associated factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Nucleolus NuA4 Histone Acetyltransferase Complex MOZ/MORF Histone Acetyltransferase Complex NuA3a Histone Acetyltransferase Complex NuA3b Histone Acetyltransferase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding	Protein Binding Histone Acetyltransferase Activity (H3-K23 Specific)
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Histone H2A Acetylation Histone H3-K23 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Histone H3-K14 Acetylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6	HATs acetylate histones HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Major depressive disorder ( 27479909) Neuroticism ( 29255261 27918536) Schizophrenia ( 25056061 29483656)	Eyebrow thickness ( 26926045)
Interacting Genes		17 interacting genes: BEND7 CYB5R3 H3C1 H4C1 LNX2 MEAF6 MPP3 PAICS PHF10 PIAS1 STAC3 STAM2 TBC1D9B TLE5 TRIM42 ZFP64 ZFY	7 interacting genes: CCDC85B FXR2 L3MBTL2 LDOC1 MRGBP PLEKHF2 TRIM54
Entrez ID		83746	64769
HPRD ID		13954	13347
Ensembl ID		ENSG00000100395	ENSG00000163875
Uniprot IDs		A0A0S2Z5X6 Q969R5	Q9HAF1
PDB IDs		2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?
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