L3MBTL2 and PAICS

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		L3MBTL2	PAICS
Description		L3MBTL histone methyl-lysine binding protein 2	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding 5-amino-4-imidazole Carboxylate Lyase Activity Cadherin Binding
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6	Purine ribonucleoside monophosphate biosynthesis
Drugs			L-Aspartic Acid
Diseases
GWAS		Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Major depressive disorder ( 27479909) Neuroticism ( 29255261 27918536) Schizophrenia ( 25056061 29483656)
Interacting Genes		17 interacting genes: BEND7 CYB5R3 H3C1 H4C1 LNX2 MEAF6 MPP3 PAICS PHF10 PIAS1 STAC3 STAM2 TBC1D9B TLE5 TRIM42 ZFP64 ZFY	11 interacting genes: CEP76 CHD3 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PRKAG1 SMARCD1 TERF1
Entrez ID		83746	10606
HPRD ID		13954	01401
Ensembl ID		ENSG00000100395	ENSG00000128050
Uniprot IDs		A0A0S2Z5X6 Q969R5	P22234
PDB IDs		2W0T 3CEY 3F70	2H31
Enriched GO Terms of Interacting Partners?
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