PAICS and L3MBTL2

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		PAICS	L3MBTL2
Description		phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	L3MBTL histone methyl-lysine binding protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm
	Molecular Function	Phosphoribosylaminoimidazole Carboxylase Activity Phosphoribosylaminoimidazolesuccinocarboxamide Synthase Activity Protein Binding ATP Binding Identical Protein Binding 5-amino-4-imidazole Carboxylate Lyase Activity Cadherin Binding	Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding
	Biological Process	'de Novo' IMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process	Chromatin Organization Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways		Purine ribonucleoside monophosphate biosynthesis	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
Drugs		L-Aspartic Acid
Diseases
GWAS			Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Major depressive disorder ( 27479909) Neuroticism ( 29255261 27918536) Schizophrenia ( 25056061 29483656)
Interacting Genes		11 interacting genes: CEP76 CHD3 FXR2 L3MBTL2 LNX1 MOB4 NIF3L1 NUDT18 PRKAG1 SMARCD1 TERF1	17 interacting genes: BEND7 CYB5R3 H3C1 H4C1 LNX2 MEAF6 MPP3 PAICS PHF10 PIAS1 STAC3 STAM2 TBC1D9B TLE5 TRIM42 ZFP64 ZFY
Entrez ID		10606	83746
HPRD ID		01401	13954
Ensembl ID		ENSG00000128050	ENSG00000100395
Uniprot IDs		P22234	A0A0S2Z5X6 Q969R5
PDB IDs		2H31	2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?
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