EDC3 and EFHC2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EDC3	EFHC2
Description		enhancer of mRNA decapping 3	EF-hand domain containing 2
Image
GO Annotations	Cellular Component	P-body Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule	Microtubule
	Molecular Function	MRNA Binding Protein Binding Identical Protein Binding Phosphodiesterase Decapping Endonuclease Activity	Calcium Ion Binding Protein Binding
	Biological Process	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Cytoplasmic MRNA Processing Body Assembly Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Regulation Of Neuron Projection Development Cellular Response To Leukemia Inhibitory Factor
Pathways		mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Craniofacial microsomia ( 26853712)	Mean arterial pressure ( 29403010)
Interacting Genes		9 interacting genes: ANXA10 DCP1A DCP1B DDX6 EFHC2 REEP5 YWHAB YWHAG ZFP36	37 interacting genes: ARHGEF5 ARMC7 CACNB4 CCDC120 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CYFIP1 DGCR6 EDC3 EFHC1 EGLN3 EMD EXOC8 FAM107A HNRNPLL JAKMIP2 KIF9 LONRF1 MAPK9 NCDN NCK2 NDOR1 NR3C1 PBLD PLOD3 PTK6 RAD51D RUNX1T1 SNRNP25 SPG21 STK16 TRIM42 TSSK3 TUBGCP4
Entrez ID		80153	80258
HPRD ID		07954	06540
Ensembl ID		ENSG00000179151	ENSG00000183690
Uniprot IDs		Q96F86	Q5JST6
PDB IDs		2VC8 2WAX 2WAY 3D3J 3D3K 6S8S	2Z13 2Z14
Enriched GO Terms of Interacting Partners?
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