EFHC2 and CYFIP1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		EFHC2	CYFIP1
Description		EF-hand domain containing 2	cytoplasmic FMR1 interacting protein 1
Image
GO Annotations	Cellular Component	Microtubule	Ruffle Extracellular Region Cytosol MRNA Cap Binding Complex Focal Adhesion Lamellipodium SCAR Complex Filopodium Tip Secretory Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body Terminal Bouton Dendritic Spine Dendritic Growth Cone Axonal Growth Cone Synapse Perinuclear Region Of Cytoplasm Excitatory Synapse Extracellular Exosome Central Region Of Growth Cone Peripheral Region Of Growth Cone Tertiary Granule Lumen
	Molecular Function	Calcium Ion Binding Protein Binding	RNA 7-methylguanosine Cap Binding Protein Binding Translation Regulator Activity Rac GTPase Binding Actin Filament Binding
	Biological Process	Regulation Of Neuron Projection Development Cellular Response To Leukemia Inhibitory Factor	Cell Morphogenesis Regulation Of Translation Axon Guidance Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly Lamellipodium Assembly Ruffle Organization Cellular Response To Insulin Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Positive Regulation Of Axon Extension Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Response To Electrical Stimulus Dendrite Extension Modification Of Synaptic Structure Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Dendrite Development Positive Regulation Of Ruffle Assembly Negative Regulation Of Synaptic Vesicle Recycling Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Mean arterial pressure ( 29403010)	Heel bone mineral density ( 30598549) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		37 interacting genes: ARHGEF5 ARMC7 CACNB4 CCDC120 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CYFIP1 DGCR6 EDC3 EFHC1 EGLN3 EMD EXOC8 FAM107A HNRNPLL JAKMIP2 KIF9 LONRF1 MAPK9 NCDN NCK2 NDOR1 NR3C1 PBLD PLOD3 PTK6 RAD51D RUNX1T1 SNRNP25 SPG21 STK16 TRIM42 TSSK3 TUBGCP4	19 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NUP98 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1
Entrez ID		80258	23191
HPRD ID		06540	05890
Ensembl ID		ENSG00000183690	ENSG00000273749
Uniprot IDs		Q5JST6	Q7L576
PDB IDs		2Z13 2Z14	3P8C 4N78
Enriched GO Terms of Interacting Partners?
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