EFHC2 and CACNB4

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		EFHC2	CACNB4
Description		EF-hand domain containing 2	calcium voltage-gated channel auxiliary subunit beta 4
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GO Annotations	Cellular Component	Microtubule	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse
	Molecular Function	Calcium Ion Binding Protein Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Regulation Of Neuron Projection Development Cellular Response To Leukemia Inhibitory Factor	Chemical Synaptic Transmission Neuromuscular Junction Development Membrane Depolarization Cardiac Conduction Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways			Presynaptic depolarization and calcium channel opening NCAM1 interactions Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs			Nimodipine Spironolactone Verapamil Mibefradil Dronedarone Trimebutine Manidipine
Diseases			Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Mean arterial pressure ( 29403010)	Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		37 interacting genes: ARHGEF5 ARMC7 CACNB4 CCDC120 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CYFIP1 DGCR6 EDC3 EFHC1 EGLN3 EMD EXOC8 FAM107A HNRNPLL JAKMIP2 KIF9 LONRF1 MAPK9 NCDN NCK2 NDOR1 NR3C1 PBLD PLOD3 PTK6 RAD51D RUNX1T1 SNRNP25 SPG21 STK16 TRIM42 TSSK3 TUBGCP4	10 interacting genes: CACNA1A CBX3 EFHC2 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3
Entrez ID		80258	785
HPRD ID		06540	09057
Ensembl ID		ENSG00000183690	ENSG00000182389
Uniprot IDs		Q5JST6	A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 H0Y476 O00305
PDB IDs		2Z13 2Z14	2D46
Enriched GO Terms of Interacting Partners?
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