EFHC2 and PTK6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EFHC2	PTK6
Description		EF-hand domain containing 2	protein tyrosine kinase 6
Image
GO Annotations	Cellular Component	Microtubule	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Regulation Of Neuron Projection Development Cellular Response To Leukemia Inhibitory Factor	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Signal Transduction Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation ERBB2 Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid
Pathways			SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization
Drugs			Vandetanib
Diseases
GWAS		Mean arterial pressure ( 29403010)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Hair shape ( 29220522) Prostate cancer ( 23535732)
Interacting Genes		37 interacting genes: ARHGEF5 ARMC7 CACNB4 CCDC120 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CYFIP1 DGCR6 EDC3 EFHC1 EGLN3 EMD EXOC8 FAM107A HNRNPLL JAKMIP2 KIF9 LONRF1 MAPK9 NCDN NCK2 NDOR1 NR3C1 PBLD PLOD3 PTK6 RAD51D RUNX1T1 SNRNP25 SPG21 STK16 TRIM42 TSSK3 TUBGCP4	16 interacting genes: APP CCDC33 DOK1 EFHC2 EGFR ERBB3 EXOC5 FCHO1 FGFR1 HIF1A KHDRBS1 KHDRBS2 LINC01139 REL STAP2 WASL
Entrez ID		80258	5753
HPRD ID		06540	03594
Ensembl ID		ENSG00000183690	ENSG00000101213
Uniprot IDs		Q5JST6	Q13882
PDB IDs		2Z13 2Z14	1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4
Enriched GO Terms of Interacting Partners?
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