VPS37B and QARS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		VPS37B	QARS1
Description		VPS37B subunit of ESCRT-I	glutaminyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Cytoplasm Endosome Plasma Membrane Endosome Membrane Midbody Late Endosome Membrane Intracellular Membrane-bounded Organelle Host Cell Extracellular Exosome	Cytoplasm Mitochondrial Matrix Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex Protein-containing Complex
	Molecular Function	Protein Binding Calcium-dependent Protein Binding	Glutamine-tRNA Ligase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Protein Targeting To Membrane Protein Targeting To Vacuole Endosomal Transport Macroautophagy Viral Life Cycle Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Of Virus Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Viral Budding Via Host ESCRT Complex	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Brain Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Tourette syndrome ( 30818990)
Interacting Genes		16 interacting genes: BYSL CDC73 DCUN1D1 ERCC1 FBF1 HGS NCK2 PRKAA1 QARS1 SH3YL1 SMARCD1 SORBS3 TLE5 TSG101 UBASH3B VPS28	39 interacting genes: ACTN2 ANXA7 APP ASL CDK4 CDKN1A CLTC CPNE3 DPPA4 DTX2 DUSP11 FAM118B GADD45A GSK3B H2AX IRF1 KCNE3 KLC3 LAMTOR3 LZTS2 MAP3K5 NLGN3 PIK3R3 PIN1 PRRC2A RARS1 RNF11 SMAD9 SMN1 STK3 TCF12 TK1 TLE5 TRAF2 TRAF4 TRIP13 TSC22D1 TTR VPS37B
Entrez ID		79720	5859
HPRD ID		07794	07223
Ensembl ID		ENSG00000139722	ENSG00000172053
Uniprot IDs		A0A024RBU0 Q9H9H4	B7Z840 P47897
PDB IDs			4R3Z 4YE6 4YE8 4YE9
Enriched GO Terms of Interacting Partners?
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