PLEKHF2 and ACY3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PLEKHF2	ACY3
Description		pleckstrin homology and FYVE domain containing 2	aminoacylase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane	Cytosol Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol Binding Metal Ion Binding	Molecular_function Aminoacylase Activity Protein Binding Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Transport	Xenobiotic Metabolic Process Biological_process Viral Process
Pathways			Aflatoxin activation and detoxification
Drugs			L-Aspartic Acid
Diseases
GWAS		Radiation response ( 20923822)	Serum metabolite levels ( 24625756) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		71 interacting genes: ACY3 AIDA AIMP2 APP APPL1 ARL14EP BEND7 BLOC1S6 BSCL2 CAVIN2 CCDC172 CCDC85B CEP44 CGGBP1 CHIC2 DPPA4 DRAP1 DTX2 DUT ESRP1 FBXO28 FHL3 FOXA1 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HEY1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NKG7 NONO NPM2 PDP1 PEX2 PRDM14 PRKAR1A PRPSAP1 RAB39A RABAC1 RADX RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SPEF1 TBX3 TCN2 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z USF1 ZNF250 ZNF263 ZNF398	14 interacting genes: AAMDC ASPA GORASP2 KRTAP10-3 KRTAP10-8 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 RARG RRAS
Entrez ID		79666	91703
HPRD ID		15147	12422
Ensembl ID		ENSG00000175895	ENSG00000132744
Uniprot IDs		Q9H8W4	A0A024R5L2 Q96HD9
PDB IDs
Enriched GO Terms of Interacting Partners?
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