ACY3 and MAP3K8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ACY3	MAP3K8
Description		aminoacylase 3	mitogen-activated protein kinase kinase kinase 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Molecular_function Aminoacylase Activity Protein Binding Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Xenobiotic Metabolic Process Biological_process Viral Process	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway
Pathways		Aflatoxin activation and detoxification	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		L-Aspartic Acid
Diseases
GWAS		Serum metabolite levels ( 24625756) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		14 interacting genes: AAMDC ASPA GORASP2 KRTAP10-3 KRTAP10-8 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 RARG RRAS	17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		91703	1326
HPRD ID		12422	01863
Ensembl ID		ENSG00000132744	ENSG00000107968
Uniprot IDs		A0A024R5L2 Q96HD9	P41279 Q6FG25
PDB IDs			4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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