C1S and IMPDH2

		C1S	IMPDH2
Description		complement C1s	inosine monophosphate dehydrogenase 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Blood Microparticle	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding	Nucleotide Binding DNA Binding RNA Binding IMP Dehydrogenase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response	GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Purine Ribonucleoside Monophosphate Biosynthetic Process Neutrophil Degranulation Lymphocyte Proliferation Oxidation-reduction Process Retina Development In Camera-type Eye Cellular Response To Interleukin-4
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa	NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-Carboxyamide-Adenine Dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Activated partial thromboplastin time ( 29403010) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 29212778) Lung cancer in never smokers ( 28604730) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 27863252)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: C1QA C1R IMPDH2 SERPING1 VKORC1	24 interacting genes: AKT1 ALS2 AMT ANKRD9 APIP APPL1 ATXN2 ATXN7 C1S CEACAM5 CLK1 CPLANE2 DCAF1 DNASE1L3 FBXL7 KLF7 PIAS4 PRMT1 PXMP2 PXN RAD54L2 RBM15B SUMO4 UBQLN4
Entrez ID		716	3615
HPRD ID		00397	00895
Ensembl ID		ENSG00000182326	ENSG00000178035
Uniprot IDs		F8WCZ6 P09871	A0A384N6C2 P12268
PDB IDs		1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H	1B3O 1NF7 1NFB 6I0M 6I0O
Enriched GO Terms of Interacting Partners?
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