PTGER3 and EFEMP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PTGER3	EFEMP2
Description		prostaglandin E receptor 3	EGF containing fibulin extracellular matrix protein 2
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GO Annotations	Cellular Component	Cell Nuclear Envelope Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Prostaglandin E Receptor Activity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Death Intestine Smooth Muscle Contraction Positive Regulation Of Fever Generation Negative Regulation Of Gastric Acid Secretion	Elastic Fiber Assembly
Pathways		Prostanoid ligand receptors G alpha (i) signalling events	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Bimatoprost Dinoprostone Misoprostol Gemeprost Limaprost
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Intelligence (MTAG) ( 29326435) Verbal declarative memory ( 25648963)	Acne (severe) ( 24927181) Birth weight ( 31043758)
Interacting Genes		23 interacting genes: ADAMTSL4 CCDC33 CDA EFEMP2 INCA1 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MEOX2 MGAT5B MKLN1 NOTCH2NLA PTGER1 REL RGS17 RGS20 SPRY2 TCF4 TRIM42	52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638
Entrez ID		5733	30008
HPRD ID		08906	05221
Ensembl ID		ENSG00000050628	ENSG00000172638
Uniprot IDs		O00325 P43115	A0A024R5G1 O95967 Q9H3D5
PDB IDs		6AK3 6M9T	2KL7
Enriched GO Terms of Interacting Partners?
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