EFEMP2 and CREB5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EFEMP2	CREB5
Description		EGF containing fibulin extracellular matrix protein 2	cAMP responsive element binding protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle	Nuclear Chromatin Nucleus Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Elastic Fiber Assembly	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription, DNA-templated
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758)	Adolescent idiopathic scoliosis ( 31417091) Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Anxiety in major depressive disorder ( 24047446) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 30061737 29892015) Attention deficit hyperactivity disorder ( 18839057) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Crohn's disease ( 23128233) Diabetic retinopathy ( 21441570) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Pre-treatment viral load in HIV-1 infection ( 31219150) Pulse pressure ( 27841878 30578418) Serum thyroid-stimulating hormone levels ( 25436638) Smoking behaviour (cigarettes smoked per day) ( 31217584) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 29403010 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638	40 interacting genes: ADAMTSL4 ATF2 COL8A1 EFEMP2 FOS FOSL1 FOSL2 JUN KIFC3 KRT15 KRT40 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LGALS13 MDFI MGAT5B MTUS2 NOTCH2NLA RBPMS RGS20 RIMBP3 SPOP SPRY1 SPRY2 TRAF2 TRIM23 TRIP6 TSGA10
Entrez ID		30008	9586
HPRD ID		05221	09896
Ensembl ID		ENSG00000172638	ENSG00000146592
Uniprot IDs		A0A024R5G1 O95967 Q9H3D5	Q02930
PDB IDs		2KL7
Enriched GO Terms of Interacting Partners?
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