EFEMP2 and LINGO1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EFEMP2	LINGO1
Description		EGF containing fibulin extracellular matrix protein 2	leucine rich repeat and Ig domain containing 1
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding
	Biological Process	Elastic Fiber Assembly	Negative Regulation Of Axonogenesis
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Axonal growth inhibition (RHOA activation)
Drugs
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Essential tremor ( 19182806) Feeling miserable ( 29500382) General factor of neuroticism ( 30867560) Hemoglobin A1c levels ( 29403010) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neuroticism ( 27089181) Risky sexual behaviors (alcohol dependence interaction) ( 28990359)
Interacting Genes		52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638	8 interacting genes: EFEMP2 FBXW7 GOLGA2 KRTAP4-12 NGFR RTN4R SPAG5 TRIM27
Entrez ID		30008	84894
HPRD ID		05221	14322
Ensembl ID		ENSG00000172638	ENSG00000169783
Uniprot IDs		A0A024R5G1 O95967 Q9H3D5	Q96FE5
PDB IDs		2KL7	2ID5 4OQT
Enriched GO Terms of Interacting Partners?
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