EFEMP2 and HHEX

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		EFEMP2	HHEX
Description		EGF containing fibulin extracellular matrix protein 2	hematopoietically expressed homeobox
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle	Nuclear Chromatin Nucleus Cytoplasm Protein-DNA Complex
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Transcription Factor Binding Eukaryotic Initiation Factor 4E Binding DNA Binding, Bending TBP-class Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Repressing Transcription Factor Binding
	Biological Process	Elastic Fiber Assembly	Negative Regulation Of Transcription By RNA Polymerase II MRNA Export From Nucleus Response To Wounding Anterior/posterior Pattern Specification Negative Regulation Of Transcription By Transcription Factor Localization Negative Regulation Of Transcription By Competitive Promoter Binding Wnt Signaling Pathway Negative Regulation Of Angiogenesis Poly(A)+ MRNA Export From Nucleus Cell Differentiation Positive Regulation Of Wnt Signaling Pathway B Cell Differentiation Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Nucleus Response To Peptide Hormone Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Leukocyte Proliferation DNA Conformation Change
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome	Type II diabetes mellitus
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758)	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 31619474) Birth weight ( 31043758 27680694) Body mass index ( 28892062) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hemoglobin A1c levels ( 29403010) Inflammatory bowel disease ( 28067908) Insulin disposition index ( 24699409) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Intraocular pressure ( 29785010) Multiple sclerosis ( 31604244 24076602 21833088) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Type 2 diabetes ( 22885922 18372903 24509480 17293876 30054458 22693455 20862305 29358691 30297969 26818947 23945395 20581827 19401414 17463246 30718926 17463248 17463249 28869590)
Interacting Genes		52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638	15 interacting genes: EFEMP2 GATA2 GATA6 JUN KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP4-12 PML PSMA3 SOX10 SOX8 TLE1 TRMT6
Entrez ID		30008	3087
HPRD ID		05221	06829
Ensembl ID		ENSG00000172638	ENSG00000152804
Uniprot IDs		A0A024R5G1 O95967 Q9H3D5	Q03014
PDB IDs		2KL7	2E1O
Enriched GO Terms of Interacting Partners?
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