MAPK7 and SH2D2A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MAPK7	SH2D2A
Description		mitogen-activated protein kinase 7	SH2 domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Cytoplasm Cytosol
	Molecular Function	MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Signaling Adaptor Activity
	Biological Process	MAPK Cascade Cell Cycle Signal Transduction Axon Guidance Regulation Of Gene Expression Peptidyl-serine Phosphorylation CAMP-mediated Signaling Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Signal Transduction Cell Proliferation Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling	VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644)	Platelet count ( 27863252) SjÃ¶gren's syndrome ( 28076899)
Interacting Genes		28 interacting genes: ACTN4 APP EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL	29 interacting genes: APPL1 ARID5A CRK DAPK1 EGFR ERBB2 ITK KDR LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1 ZYG11B
Entrez ID		5598	9047
HPRD ID		03952	05152
Ensembl ID		ENSG00000166484	ENSG00000027869
Uniprot IDs		A0A024QZ20 Q13164	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs		2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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