SH2D2A and MFHAS1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
4

Data Source:
BioGRID (pull down)

		SH2D2A	MFHAS1
Description		SH2 domain containing 2A	malignant fibrous histiocytoma amplified sequence 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Mitochondrion Lysosome Cytoskeleton
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Signaling Adaptor Activity	Protein Binding GTP Binding Ubiquitin Protein Ligase Binding Protein Phosphatase 2A Binding
	Biological Process	Angiogenesis Signal Transduction Cell Proliferation Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Inflammatory Response Erythrocyte Differentiation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Dephosphorylation Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade
Pathways		VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Platelet count ( 27863252) SjÃ¶gren's syndrome ( 28076899)	Acne (severe) ( 24927181) Adventurousness ( 30643258) Age at first sexual intercourse ( 27089180) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Chronic obstructive pulmonary disease ( 30804561) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels ( 23823483) Mood instability ( 29187730) Neuroticism ( 29255261) Skin aging (microtopography measurement) ( 28502801) Systemic lupus erythematosus ( 28714469) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		29 interacting genes: APPL1 ARID5A CRK DAPK1 EGFR ERBB2 ITK KDR LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1 ZYG11B	88 interacting genes: ABLIM1 AGFG1 AHCYL1 AHDC1 ANKRD13A ANKRD13D ANKS4B APEX2 AURKB BAG2 CABP4 CALM1 CALML3 CALU CAPRIN1 CBLB CCDC149 CCDC43 CDC42EP3 CEBPZ CEP85 CETN3 CHGB CLK1 COPB2 CRTC2 CUEDC1 CYREN DDI1 DRC3 E2F4 EGLN2 ESRRG ETV5 FGF16 FGFR1 FOXN3 GAK GAS2L3 GPBP1L1 GSDMD GTSF1 HIC2 IFTAP KLHDC4 LIMA1 LIMK1 MAP3K4 MRGBP NEK1 NEK11 PDCL PGRMC2 PJA2 PMM1 POLA2 POLI PPARG PRKAG2 PSME3IP1 RASL11B RCN2 RHBDD1 ROR1 RPAP3 RTKN SELENOS SH2D2A SLC4A1AP SMTNL2 SNAI1 STK25 STN1 STUB1 SUPT4H1 TADA3 TAS2R60 TBC1D22B TOX2 TRAPPC2 TRIM22 TTC27 UBL7 VGLL4 VN1R1 WWTR1 ZFAND5 ZMYM5
Entrez ID		9047	9258
HPRD ID		05152	12010
Ensembl ID		ENSG00000027869	ENSG00000147324
Uniprot IDs		Q5UBZ2 Q5UBZ3 Q9NP31	Q9Y4C4
PDB IDs
Enriched GO Terms of Interacting Partners?
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