SH2D2A and LRRFIP1

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		SH2D2A	LRRFIP1
Description		SH2 domain containing 2A	LRR binding FLII interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Signaling Adaptor Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded RNA Binding Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Angiogenesis Signal Transduction Cell Proliferation Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Type I Interferon Production Negative Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		VEGFA-VEGFR2 Pathway	Signaling by cytosolic FGFR1 fusion mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by FGFR1 in disease
Drugs
Diseases
GWAS		Platelet count ( 27863252) SjÃ¶gren's syndrome ( 28076899)	Adiposity ( 23505185) Longevity ( 30294719)
Interacting Genes		29 interacting genes: APPL1 ARID5A CRK DAPK1 EGFR ERBB2 ITK KDR LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1 ZYG11B	6 interacting genes: CEP44 FBXO7 FLII MED4 SERPINB5 SH2D2A
Entrez ID		9047	9208
HPRD ID		05152	04460
Ensembl ID		ENSG00000027869	ENSG00000124831
Uniprot IDs		Q5UBZ2 Q5UBZ3 Q9NP31	A0A0F7NGI8 B4DPC0 Q32MZ4
PDB IDs			4H22
Enriched GO Terms of Interacting Partners?
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