SH2D2A and SPTB

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		SH2D2A	SPTB
Description		SH2 domain containing 2A	spectrin beta, erythrocytic
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Protein-containing Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Signaling Adaptor Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Angiogenesis Signal Transduction Cell Proliferation Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	MAPK Cascade ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Actin Filament Capping
Pathways		VEGFA-VEGFR2 Pathway	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases			Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Platelet count ( 27863252) SjÃ¶gren's syndrome ( 28076899)	Daytime sleep phenotypes ( 27126917) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Obesity-related traits ( 23251661) Pediatric areal bone mineral density (radius) ( 28181694) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Type 2 diabetes ( 31049640)
Interacting Genes		29 interacting genes: APPL1 ARID5A CRK DAPK1 EGFR ERBB2 ITK KDR LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1 ZYG11B	14 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN EPB41 MAPT NCAM1 SH2D2A SPTA1 SPTAN1 STAT1 YWHAQ
Entrez ID		9047	6710
HPRD ID		05152	01686
Ensembl ID		ENSG00000027869	ENSG00000070182
Uniprot IDs		Q5UBZ2 Q5UBZ3 Q9NP31	P11277
PDB IDs			1S35 3EDU 3F57 3KBT 3KBU 3LBX
Enriched GO Terms of Interacting Partners?
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