MAPK7 and EGLN3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MAPK7	EGLN3
Description		mitogen-activated protein kinase 7	egl-9 family hypoxia inducible factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	MAPK Cascade Cell Cycle Signal Transduction Axon Guidance Regulation Of Gene Expression Peptidyl-serine Phosphorylation CAMP-mediated Signaling Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways		ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Vitamin C Roxadustat
Diseases
GWAS		Alzheimer's disease ( 30636644)	Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)
Interacting Genes		28 interacting genes: ACTN4 APP EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL	25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83
Entrez ID		5598	112399
HPRD ID		03952	06972
Ensembl ID		ENSG00000166484	ENSG00000129521
Uniprot IDs		A0A024QZ20 Q13164	B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9
PDB IDs		2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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