PRKAB2 and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		PRKAB2	PIAS2
Description		protein kinase AMP-activated non-catalytic subunit beta 2	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding Identical Protein Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		Adenosine monophosphate Acetylsalicylic acid
Diseases
GWAS
Interacting Genes		74 interacting genes: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FDX1 FLNC GATA1 GATAD2B GET4 GOLGA2 GRN IHO1 IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PNMA1 PRDM14 PRKAA1 PRKAG1 PRKAG2 PSME3 PYGM RACK1 RBPMS REL RHEBL1 RIMBP3 SPRY2 SSX2IP STX11 STX19 TADA2A TASOR2 TCF4 TLE5 TP53 TP53BP2 TRAF1 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32	72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451
Entrez ID		5565	9063
HPRD ID		04117	06944
Ensembl ID		ENSG00000131791	ENSG00000078043
Uniprot IDs		O43741	A0A024RC49 O75928 Q2TA77
PDB IDs		2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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