PRKAB2 and EPM2A

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PRKAB2	EPM2A
Description		protein kinase AMP-activated non-catalytic subunit beta 2	EPM2A glucan phosphatase, laforin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex	Nucleus
	Molecular Function	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding Identical Protein Binding	Protein Binding
	Biological Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator	Positive Regulation Of Macroautophagy Negative Regulation Of TOR Signaling
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs		Adenosine monophosphate Acetylsalicylic acid
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS			Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 27863252) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)
Interacting Genes		74 interacting genes: ADAMTSL4 BANP BEND5 BLZF1 CALCOCO2 CASP6 CCDC33 CDX4 CREB3L1 CRX CSNK2B DAO DDIT4L DICER1 DST EPM2A FDX1 FLNC GATA1 GATAD2B GET4 GOLGA2 GRN IHO1 IKZF1 IKZF3 KCTD5 KLF15 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-4 LZTS2 MAGED1 MDFI MEOX2 NEBL PIAS2 PNMA1 PRDM14 PRKAA1 PRKAG1 PRKAG2 PSME3 PYGM RACK1 RBPMS REL RHEBL1 RIMBP3 SPRY2 SSX2IP STX11 STX19 TADA2A TASOR2 TCF4 TLE5 TP53 TP53BP2 TRAF1 TRAF2 TRIM10 UBXN11 YY1AP1 ZBTB32	16 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 NHLRC1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS
Entrez ID		5565	7957
HPRD ID		04117	06345
Ensembl ID		ENSG00000131791	ENSG00000112425
Uniprot IDs		O43741	H0UI04 O95278
PDB IDs		2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E	4R30 4RKK
Enriched GO Terms of Interacting Partners?
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