PIAS2 and ACY3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PIAS2	ACY3
Description		protein inhibitor of activated STAT 2	aminoacylase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body Nuclear Speck	Cytosol Apical Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity	Molecular_function Aminoacylase Activity Protein Binding Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway	Xenobiotic Metabolic Process Biological_process Viral Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Aflatoxin activation and detoxification
Drugs			L-Aspartic Acid
Diseases
GWAS			Serum metabolite levels ( 24625756) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451	14 interacting genes: AAMDC ASPA GORASP2 KRTAP10-3 KRTAP10-8 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 RARG RRAS
Entrez ID		9063	91703
HPRD ID		06944	12422
Ensembl ID		ENSG00000078043	ENSG00000132744
Uniprot IDs		A0A024RC49 O75928 Q2TA77	A0A024R5L2 Q96HD9
PDB IDs		2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?