PPL and RALBP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PPL	RALBP1
Description		periplakin	ralA binding protein 1
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GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Extracellular Exosome	Cytosol Membrane
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	GTPase Activator Activity Protein Binding Ral GTPase Binding Transmembrane Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity Rac GTPase Binding
	Biological Process	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	Endocytosis Chemotaxis Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Transport Doxorubicin Transport Drug Transmembrane Export
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	Rho GTPase cycle
Drugs
Diseases
GWAS		Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)	LDL cholesterol ( 30275531)
Interacting Genes		24 interacting genes: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 LARP1 OPRM1 PPHLN1 PTEN RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1	30 interacting genes: AMOTL2 AP2M1 C1orf216 CASP8 CCNB1 CEP57 FADD GSE1 HOOK2 HSF1 IKBKG PLCG2 PPL PRKACA PRKCA RAC1 RALA RALB REPS1 REPS2 RHOU SMARCE1 SYNJ2BP TBRG1 TFPT TNIP1 TRAF2 TSFM ZBTB38 ZNF707
Entrez ID		5493	10928
HPRD ID		04187	09013
Ensembl ID		ENSG00000118898	ENSG00000017797
Uniprot IDs		O60437	Q15311
PDB IDs		4Q28	2KWH 2KWI 2MBG
Enriched GO Terms of Interacting Partners?
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