RALBP1 and HOOK2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RALBP1	HOOK2
Description		ralA binding protein 1	hook microtubule tethering protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Cytoplasm Centrosome Cytosol Microtubule HOPS Complex Intracellular Membrane-bounded Organelle FHF Complex
	Molecular Function	GTPase Activator Activity Protein Binding Ral GTPase Binding Transmembrane Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity Rac GTPase Binding	Protein Binding Microtubule Binding Identical Protein Binding Dynein Light Intermediate Chain Binding
	Biological Process	Endocytosis Chemotaxis Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Transport Doxorubicin Transport Drug Transmembrane Export	Endocytosis Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Early Endosome To Late Endosome Transport
Pathways		Rho GTPase cycle
Drugs
Diseases
GWAS		LDL cholesterol ( 30275531)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Monocyte count ( 27863252)
Interacting Genes		30 interacting genes: AMOTL2 AP2M1 C1orf216 CASP8 CCNB1 CEP57 FADD GSE1 HOOK2 HSF1 IKBKG PLCG2 PPL PRKACA PRKCA RAC1 RALA RALB REPS1 REPS2 RHOU SMARCE1 SYNJ2BP TBRG1 TFPT TNIP1 TRAF2 TSFM ZBTB38 ZNF707	41 interacting genes: ABLIM1 AKTIP ANKRD11 ANKRD36BP1 AP1M1 APEX2 CCDC33 CWF19L2 DUSP13 EPS8 FAM107A HAUS1 HOOK1 HOOK3 IQCE ITSN2 KANSL1 KAT7 KIAA0408 KLK15 MCM10 PIMREG PSMF1 RALBP1 RIBC2 RITA1 RNF6 SMARCB1 SUV39H1 TPM3 TRMT1 USP2 UTP14A UTP14C VPS16 VPS41 ZBTB47 ZC2HC1C ZC3H14 ZNF250 ZNF638
Entrez ID		10928	29911
HPRD ID		09013	09698
Ensembl ID		ENSG00000017797	ENSG00000095066
Uniprot IDs		Q15311	Q96ED9
PDB IDs		2KWH 2KWI 2MBG
Enriched GO Terms of Interacting Partners?
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