PPL and ITSN1

Number of citations of the paper that reports this interaction (PubMedID 22558309)
18

Data Source:
BioGRID (two hybrid)

		PPL	ITSN1
Description		periplakin	intersectin 1
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Extracellular Exosome	Nuclear Envelope Cytosol Plasma Membrane Clathrin-coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuronal Cell Body Dendritic Spine Calyx Of Held Recycling Endosome Apical Dendrite Presynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	Exocytosis G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Brain Development Protein Transport Viral Process Positive Regulation Of Kinase Activity Cellular Protein Localization Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Membrane Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)	Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) QT interval ( 29213071) Red cell distribution width ( 27863252) Tonsillectomy ( 27182965 28928442)
Interacting Genes		24 interacting genes: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 LARP1 OPRM1 PPHLN1 PTEN RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1	85 interacting genes: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAP3K20 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SGIP1 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZFPM2
Entrez ID		5493	6453
HPRD ID		04187	03898
Ensembl ID		ENSG00000118898	ENSG00000205726
Uniprot IDs		O60437	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs		4Q28	1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T
Enriched GO Terms of Interacting Partners?
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