PPL and PPHLN1

Number of citations of the paper that reports this interaction (PubMedID 12853457)
9

Data Source:
HPRD (two hybrid)

		PPL	PPHLN1
Description		periplakin	periphilin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Extracellular Exosome	Nucleoplasm Chromosome Golgi Apparatus Cytosol
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	RNA Binding Protein Binding
	Biological Process	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	Keratinization Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Methylation-dependent Chromatin Silencing Protein Localization To Heterochromatin
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)	Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653)
Interacting Genes		24 interacting genes: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 LARP1 OPRM1 PPHLN1 PTEN RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1	24 interacting genes: APP BCL2L1 BRCA1 CASP5 CCDC57 CDC37 CDK6 CLK1 FBXO7 MTUS2 NAGK PAXIP1 PPL SEPTIN8 SNCAIP SQSTM1 SRPK2 TGM2 TOMM20 TOPBP1 TP53BP2 TSGA10 UFD1 VIM
Entrez ID		5493	51535
HPRD ID		04187	10488
Ensembl ID		ENSG00000118898	ENSG00000134283
Uniprot IDs		O60437	Q8NEY8
PDB IDs		4Q28
Enriched GO Terms of Interacting Partners?
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