PPL and AHCYL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PPL	AHCYL1
Description		periplakin	adenosylhomocysteinase like 1
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GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	RNA Binding Adenosylhomocysteinase Activity Protein Binding Identical Protein Binding
	Biological Process	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification	MRNA Polyadenylation Protein Export From Nucleus One-carbon Metabolic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Anion Transport Response To Calcium Ion Regulation Of Cardiac Conduction
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)	Height ( 31562340)
Interacting Genes		24 interacting genes: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 LARP1 OPRM1 PPHLN1 PTEN RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1	17 interacting genes: BID CDKN2C DACH1 GEM HGS ITPR1 LRRK2 MEOX2 MFHAS1 PPL PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 ZNF165
Entrez ID		5493	10768
HPRD ID		04187	07613
Ensembl ID		ENSG00000118898	ENSG00000168710
Uniprot IDs		O60437	A0A024R0A8 O43865
PDB IDs		4Q28	3MTG
Enriched GO Terms of Interacting Partners?
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