ITSN2 and RUFY1

Number of citations of the paper that reports this interaction (PubMedID 22558309)
18

Data Source:
BioGRID (two hybrid)

		ITSN2	RUFY1
Description		intersectin 2	RUN and FYVE domain containing 1
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GO Annotations	Cellular Component	Cytoplasm Centrosome Extracellular Exosome	Cytoplasm Endosome Cytosol Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	Protein Binding Lipid Binding SH3 Domain Binding SH2 Domain Binding Metal Ion Binding
	Biological Process	Endocytosis Positive Regulation Of Signal Transduction Viral Process Positive Regulation Of Dendrite Extension	Phosphatidylinositol Biosynthetic Process Endocytosis Small GTPase Mediated Signal Transduction Protein Transport Regulation Of Endocytosis
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067)	Daytime sleep phenotypes ( 27126917) Dental caries (decayed and filled deciduous teeth) ( 31533690) Eating disorders ( 22911880) Lung cancer ( 28604730)
Interacting Genes		77 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	16 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX EPHA3 GIT2 ITSN2 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A TXNDC17 UTP25
Entrez ID		50618	80230
HPRD ID		09193	15282
Ensembl ID		ENSG00000198399	ENSG00000176783
Uniprot IDs		A6H8W8 Q9NZM3	A8K7B1 Q96T51
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO	2YQM 2YW8
Enriched GO Terms of Interacting Partners?
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