ITSN2 and NBR1

Number of citations of the paper that reports this interaction (PubMedID 22558309)
18

Data Source:
BioGRID (two hybrid)

		ITSN2	NBR1
Description		intersectin 2	NBR1 autophagy cargo receptor
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GO Annotations	Cellular Component	Cytoplasm Centrosome Extracellular Exosome	Phagophore Assembly Site Nucleoplasm Mitochondrion Lysosome Late Endosome Autophagosome Cytosol Membrane Nuclear Body M Band Intracellular Membrane-bounded Organelle Receptor Complex
	Molecular Function	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Endocytosis Positive Regulation Of Signal Transduction Viral Process Positive Regulation Of Dendrite Extension	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Pexophagy Pexophagy
Drugs
Diseases
GWAS		Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067)
Interacting Genes		77 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	21 interacting genes: ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP1LC3B MAP2K4 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1
Entrez ID		50618	4077
HPRD ID		09193	01326
Ensembl ID		ENSG00000198399	ENSG00000188554
Uniprot IDs		A6H8W8 Q9NZM3	A0A024R1V3 B7Z5R6 Q14596
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO	1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE
Enriched GO Terms of Interacting Partners?
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