ITSN2 and LTBP4

Number of citations of the paper that reports this interaction (PubMedID 22558309)
18

Data Source:
BioGRID (two hybrid)

		ITSN2	LTBP4
Description		intersectin 2	latent transforming growth factor beta binding protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding	Transforming Growth Factor Beta-activated Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Transforming Growth Factor Beta Binding
	Biological Process	Endocytosis Positive Regulation Of Signal Transduction Viral Process Positive Regulation Of Dendrite Extension	Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organism Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Proteolysis Growth Hormone Secretion Regulation Of Cell Differentiation
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Molecules associated with elastic fibres
Drugs
Diseases			Cutis laxa with severe pulmonary, gastrointestinal, and urinary abnormalities; Urban-Rifkin-Davis syndrome
GWAS		Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067)	Lung function (FEV1/FVC) ( 26635082 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		77 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	11 interacting genes: ATN1 ATXN7 CACNA1A CRKL CRY1 FBLN1 FRAT1 GFI1B ITSN2 RAC1 TGFB1
Entrez ID		50618	8425
HPRD ID		09193	05274
Ensembl ID		ENSG00000198399	ENSG00000090006
Uniprot IDs		A6H8W8 Q9NZM3	A0A0C4DH07 B3KXY6 Q8N2S1
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?
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