NBR1 and CIB1

Number of citations of the paper that reports this interaction (PubMedID 11856312)
16

Data Source:
HPRD (in vitro, two hybrid)

		NBR1	CIB1
Description		NBR1 autophagy cargo receptor	calcium and integrin binding 1
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleoplasm Mitochondrion Lysosome Late Endosome Autophagosome Cytosol Membrane Nuclear Body M Band Intracellular Membrane-bounded Organelle Receptor Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Plasma Membrane Membrane Apical Plasma Membrane Lamellipodium Dendrite Growth Cone Vesicle Filopodium Tip Ruffle Membrane Sarcolemma Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding Mitogen-activated Protein Kinase Binding	Calcium Ion Binding Protein Binding Protein C-terminus Binding Calcium-dependent Protein Kinase Inhibitor Activity Ras GTPase Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Membrane Anchor Ion Channel Binding
	Biological Process	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation	Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell-matrix Adhesion Response To Ischemia Double-strand Break Repair Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Endomitotic Cell Cycle Cell Adhesion Spermatid Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Neuron Projection Development Platelet Formation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Cytoplasmic Microtubule Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Thrombopoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Division Regulation Of Cell Division Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Male Germ Cell Proliferation
Pathways		Pexophagy Pexophagy
Drugs			Calcium Citrate Calcium Phosphate
Diseases
GWAS
Interacting Genes		21 interacting genes: ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP1LC3B MAP2K4 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1	20 interacting genes: AURKB CDK4 EXOSC10 FEZ1 IFI6 ITGA2B NBR1 NRIP1 PAX3 PLK2 PLK3 PRKDC PSEN1 PSEN2 PTK2 RAC3 TERT UBR5 WAS ZDHHC17
Entrez ID		4077	10519
HPRD ID		01326	03800
Ensembl ID		ENSG00000188554	ENSG00000185043
Uniprot IDs		A0A024R1V3 B7Z5R6 Q14596	A0A140VK09 Q99828
PDB IDs		1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE	1DGU 1DGV 1XO5 1Y1A 2L4H 2L4I 2LM5
Enriched GO Terms of Interacting Partners?
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