OTX1 and GRN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		OTX1	GRN
Description		orthodenticle homeobox 1	granulin precursor
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin	Extracellular Region Extracellular Space Cell Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Chaperone Binding
	Biological Process	Anterior/posterior Pattern Specification Metencephalon Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis	Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Protein Stabilization Regulation Of Nervous System Development Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Aspartic-type Peptidase Activity Positive Regulation Of Lysosome Organization
Pathways			Neutrophil degranulation
Drugs
Diseases			Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Neurociticism ( 29500382) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258)	Blood protein levels ( 30072576 29875488) Intracranial volume ( 22504418) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)
Interacting Genes		47 interacting genes: ADAMTSL4 CHIC2 CHRD COMP DPY30 FBLN5 GEMIN8P4 GRN KCNK16 KRT81 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE4A MDFI MGAT5B MTNR1B RBPMS RGS17 RGS20 SMARCC1 SPRY1 SPRY2 TLE4 TNS2 VWC2L	38 interacting genes: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 SPRY2 TAT TGM2 TOP3B YY1
Entrez ID		5013	2896
HPRD ID		08964	00733
Ensembl ID		ENSG00000115507	ENSG00000030582
Uniprot IDs		P32242	P28799
PDB IDs			1G26 2JYE 2JYT 2JYU 2JYV
Enriched GO Terms of Interacting Partners?
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